Rat Astrocytes-hippocampal

Description

Rat Hippocampal Astrocytes are primary glial cells isolated from the hippocampal region of rats. These stellate cells express mature astrocytic markers such as GFAP, S100β, and GLAST, and form extensive processes supporting synaptic regions. Functionally, they regulate extracellular neurotransmitter and ion homeostasis, support neurogenesis, and contribute to the tripartite synapse by releasing gliotransmitters that modulate neuronal excitability and plasticity. In the adult hippocampus, these astrocytes also display age-dependent changes in antioxidative defenses and glutamate transporters, which affect synaptic function in aging brains. Recent studies show overexpression of GDNF in hippocampal astrocytes enhances branching complexity and process length—underscoring their potential in neurodegenerative disease models. Additionally, activated hippocampal astrocytes regulate anxiety-like behavior via ATP-dependent synaptic modulation in the dentate gyrus. Each lot undergoes rigorous screening and isolation procedures and is tested to ensure it is free from contamination by Mycoplasma, Fungi, Yeast, and Bacteria.