Rat cardiac fibroblasts, Adult

Description

Rat Cardiac Fibroblasts, Adult are primary mesenchymal cells isolated from healthy adult rat ventricular tissue, representing the most abundant non-myocyte cell type in the heart. These cells exhibit a characteristic spindle-shaped morphology and plastic-adherent growth properties. They play a vital role in synthesizing and remodeling extracellular matrix (ECM) components, particularly types I/III collagen, under both physiological and pathological conditions. Upon stimulation with factors such as angiotensin II or aldosterone, these fibroblasts significantly enhance collagen production while suppressing metalloproteinase‐mediated degradation, recapitulating fibrotic processes seen in hypertensive heart disease and heart failure. They are positive for vimentin. These cells are cryopreserved at an early passage. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.