Rat Dermal Fibroblasts-adult

Description

Rat Dermal Fibroblasts-adult are primary cells isolated from the dermal layer of adult rat skin. These spindle-shaped, adherent cells are collected at an early passage and cryopreserved to preserve their proliferative and functional integrity. Adult dermal fibroblasts play a vital role in extracellular matrix (ECM) synthesis, wound healing, and tissue remodeling by secreting key structural proteins such as type I and III collagen, fibronectin, and elastin. They express key mesenchymal markers like vimentin and α-SMA. Compared to neonatal fibroblasts, adult fibroblasts generally exhibit lower proliferative capacity and a different profile of growth factor responsiveness. These cells are commonly used in dermatological models to study inflammation, skin regeneration, and toxicological screening. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, Fungi, Yeast and Bacteria.