Rat Liver Kupffer Cells

Description

Rat Liver Kupffer Cells are specialized macrophages isolated from the sinusoidal lining of healthy rat livers and cryopreserved following primary culture. These stellate, non-proliferative kupffer cells in liver serve as key mediators of hepatic immune surveillance, phagocytosis, and clearance of pathogens, apoptotic cells, and cellular debris. Kupffer cells express characteristic markers such as CD68, F4/80, and CD163, and secrete immunomodulatory cytokines including TNF-α, IL-6, and IL-10. They play a central role in maintaining liver homeostasis, regulating rat liver function, and contribute to the pathogenesis of liver diseases such as alcoholic liver disease, non-alcoholic fatty liver disease, and metal-induced hepatotoxicity. Due to their immunological function and crosstalk with hepatocytes, they are widely used in studies of liver inflammation, drug metabolism, and toxicology. Kupffer cells cannot be subcultured and should not be subjected to repeated freeze-thaw cycles to maintain functional integrity.