Rat Neurons-Ventral Spinal Cord

Description

Rat ventral spinal cord neurons (RN-vsc) are primary neurons derived from rat spinal tissue and do not proliferate in vitro. These neurons are polarized, excitable cells responsible for transmitting motor commands from the brain to peripheral muscles via efferent pathways in the ventral spinal cord. Morphologically, they exhibit typical neuronal features, including a cell body with extending dendrites and a single axon. Functionally, ventral spinal cord neurons integrate and relay motor signals, facilitating voluntary movement. Dysregulation or damage to these neurons, such as in spinal cord injury (SCI), disrupts motor output, leading to paralysis. Key molecular markers include β-tubulin III and MAP2. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.