Rat Peritoneal Smooth Muscle Cells

Description

Rat Peritoneal Smooth Muscle Cells (SMCs) are mesenchymal-derived contractile cells primarily isolated from the peritoneal lining. These cells exhibit a spindle-shaped or elongated morphology, characteristic of smooth muscle cells. Rat peritoneal SMCs play a crucial role in maintaining peritoneal integrity, regulating peritoneal fluid dynamics, and facilitating wound repair through contraction and extracellular matrix (ECM) secretion. Their contractility is modulated by calcium-dependent signaling pathways and autonomic nervous system inputs. They are distinguished by their expression of key contractile proteins, including α-smooth muscle actin (α-SMA), calponin, smooth muscle myosin heavy chain (SM-MHC) and desmin, which are essential for their contractile function. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.