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Tumor Cell Lines

SHP-77

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SHP-77 was established in 1977 being derived from a non-encapsulated primary lung tumor from the apical portion of the upper lobe of the left lung. The patient was a 54 year old male with blood type O, Rh+. The cell line has a variety of unusual characteristics including the morphology of an undifferentiated large cell […]
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Product Code

SHP77

Species

Human

Cat.No

ABC-TC1319

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Lung

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Lung Cancer Cell Lines

Description

SHP-77SHP-77 is a human small cell lung carcinoma (SCLC) cell line established in 1977 from a non-encapsulated primary tumor in the apical upper lobe of the left lung of a 54-year-old Caucasian male patient. This cell line exhibits epithelial-like morphology with mixed growth properties, showing both loosely adherent clusters and suspension aggregates. Cytogenetic analysis reveals mutations in key oncogenic drivers including KRAS and TP53 (1). SHP-77 expresses various neuroendocrine differentiation markers such as L-dopa decarboxylase, dense core secretory granules, neural cell adhesion molecule (NCAM), and surface antigens CD56/CD57 (HNK-1/Leu-7). The cell line demonstrates tumorigenic potential in immunodeficient mice, making it valuable for studying SCLC progression and immunotherapy response.

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Citation

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Application

  • The SHP-77 cell line is a versatile research model widely used in immune-oncology and cytotoxicity studies related to small cell lung carcinoma (SCLC). It serves as an in vitro target in 51Cr and 111In release cytotoxicity assays, facilitating the study of cytotoxic immune responses. In vivo, SHP-77 is used in xenograft models to evaluate immune reactivity in nude mice, particularly using cells and serum from SCLC patients. Furthermore, they play a crucial role in assessing the immune status and therapeutic response in individuals with small cell lung carcinoma (SCLC) who have undergone radiation or chemotherapy treatments, offering valuable insights into treatment efficacy and resistance mechanisms.

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