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SHP-77 | ||||
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| Product Name | SHP-77 | |||
| Price | Get Quote | |||
| Product Code | SHP77 | |||
| Cat.No | ABC-TC1319 | Species | Human | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description |
Why choose SHP-77 from AcceGen? The SHP-77 cell line from AcceGen boasts high viability and quality, having been incubated under optimal conditions and cryopreserved by skilled operators. It is delivered sterile and rigorously screened for mycoplasma contamination, with its identity verified through STR analysis, ensuring a reliable and top-quality research tool. | |||
| Source Organ | Lung | |||
| Recommended Medium And Supplement | RPMI 1640 + 10% FBS | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY The SHP-77 cell line finds valuable applications in various research contexts. It serves as an in vitro target for 51Cr and 111In release cytotoxicity assays, facilitating the study of cytotoxic immune responses. Additionally, SHP-77 cells are well-suited for in vitro assays in nude mice, enabling the evaluation of immune reactivity using cells and serum from lung cancer patients. Furthermore, they play a crucial role in assessing the immune status of individuals with small cell lung carcinoma (SCLC) who have undergone radiation or chemotherapy treatments, offering valuable insights into treatment outcomes and immune responses. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Product Type | Human Lung Cancer Cell Lines | |||
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The SHP-77 cell line, established in 1977, originates from a non-encapsulated primary lung tumor located in the apical portion of the upper lobe of the left lung. This cell line exhibits a distinctive profile, combining the morphological characteristics of an undifferentiated large cell variant of small cell lung carcinoma (SCLC) with the biochemical properties typical of classical SCLC. Notably, SHP-77 cells express neural cell adhesion molecule (NCAM), NHK-1, CD56, and Leu-7 (HNK-1; CD57) on their cell surface, in addition to displaying neuroendocrine markers like L-dopa decarboxylase and dense core secretory granules. Ultrastructural analysis by electron microscopy has revealed the presence of gland formation and intracytoplasmic lamellar bodies. Furthermore, SHP-77 cells exhibit tumorigenic potential in nude mice, forming well-circumscribed nodules without metastatic dissemination, and are characterized by a reported doubling time of 96 hours.
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