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| Product Code | Suit-2; SUIT 2; SUIT2; Suit2; SUIzo Tumor-2 |
| Species | Human |
| Cat.No | ABC-TC1175 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
SUIT-2 is a human pancreatic cancer cell line derived from a liver metastasis of moderately differentiated tubular adenocarcinoma in a Japanese male patient. The cells exhibit an epithelial-like morphology with two distinct subpopulations under phase-contrast microscopy: one spindle-shaped and elongated, the other polygonal and epithelial. SUIT-2 cells express several pancreatic ductal markers including carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), CSPG2/versican, and Mac25/angiomodulin. Electron microscopy confirms features of pancreatic ductal epithelium. Karyotype analysis shows aneuploidy, consistent with malignant transformation. SUIT-2 cells are tumorigenic and metastatic, capable of forming tumors and spreading to regional lymph nodes in nude mouse xenografts.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Chen, W.C., To, M.D., Westcott, P.M., Delrosario, R., Kim, I.J., Philips, M., Tran, Q., Bollam, S.R., Goodarzi, H., Bayani, N. and Mirzoeva, O., 2021. Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells. Nature communications, 12(1), pp.1-14.
SUIT-2 is a useful tool to investigate the biological activity of pancreatic ductal adenocarcinoma, identify novel targets or markers for diagnosis, prognosis, and therapy, and contribute to understanding of the interactions between cancer and the host. For example, SUIT-2 can be used to demonstrate how growth factors regulate cell proliferation of tumor cells and the impact of motility-related factors on migration and metastasis.
