For research use only
| Cat No. | ABC-TC1217 |
| Product Type | Human Breast Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Ductal Cancer |
| Product Code | T-47-D; T47-D; T47D:A; T47D |
T-47D breast cancer cells expressing WNT7B support endocrine signaling research, drug screening, and ductal carcinoma biology studies in models.
T-47D is a human breast epithelial tumor cell line originally isolated from a pleural effusion obtained from a 54-year-old female patient with infiltrating invasive ductal carcinoma. T-47D exhibits cohesive, epithelial-like morphology in adherent monolayer culture. It is capable to form colonies in soft agar. The karyotype of T-47D is hypotriploid, with a modal chromosome number of 65 in ~50% of cells and a low polyploidy rate (~0. 8%). T‑47D cells are strongly ERα-positive and PR-positive, with progesterone receptor levels exceptionally high, uniquely unregulated by estradiol, distinguishing them from MCF‑7. These cells are known for their high expression of the Wnt-7b oncogene and demonstrates estrogen receptor-dependent proliferation. T-47D is widely used in cancer research including mechanistic studies, drug screening and hormone signaling studies due to its tumorigenic properties.
| Product Code | T-47-D; T47-D; T47D:A; T47D |
| Species | Human |
| Cat.No | ABC-TC1217 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Ductal Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Breast Cancer Cell Lines |
The T-47D cell line plays a pivotal role in advancing breast cancer and hormone receptor-related research. These cells have been instrumental in investigating the impact of progesterone on breast cancer and in deciphering the transcriptional regulation induced by various therapeutic agents. Furthermore, T-47D cells can be used to establish xenograft models in immunodeficient mice, enabling researchers to perform drug testing, assess receptor status, and monitor changes in angiogenesis—thus offering crucial insights into cancer treatment strategies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
