For research use only
| Cat No. | ABC-TC1337 |
| Product Type | Human Liver Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | THLE2; Transformed Human Liver Epithelial-2 |
THLE-2 liver epithelial cells immortalized with SV40,non-tumorigenic,metabolize pro-carcinogens, ideal for liver toxicity,drug metabolism,and HCC studies.
THLE-2 is a human immortalized normal liver epithelial cell line derived from adult liver tissue immortalized by infecting primary adult liver cells with recombinant SV40 large T antigen. These cells exhibit typical epithelial morphology with polygonal shapes and tight cell-cell contacts, forming a monolayer in culture. THLE-2 cells retain many liver-specific functions, including expression of cytochrome P450 enzymes (e.g., CYP3A4, CYP1A2) and albumin production, making them a reliable model for hepatic biology. They are non-tumorigenic and widely used to study liver metabolism, toxicity, and disease mechanisms such as hepatitis and hepatocellular carcinoma initiation. THLE-2 cells maintain stable karyotypes and express epithelial markers such as cytokeratin 18. THLE-2 ideal for pharmacotoxicological studies, hepatic metabolism, and hepatocellular carcinoma research.
| Product Code | THLE2; Transformed Human Liver Epithelial-2 |
| Species | Human |
| Cat.No | ABC-TC1337 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Liver Cell Lines |
THLE-2 cells can serve as useful models for xenobiotic studies. They are commonly used to study xenobiotic metabolism and detoxification pathways. These cells are also employed as an lab-based system for drug toxicity tests, allowing researchers to assess the potential adverse effects of drugs and other substances on liver function. Additionally, THLE-2 cells are valuable tools for studying early events in hepatocarcinogenesis, offering insights into the development and progression of this type of liver cancer.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
