For research use only
| Cat No. | ABC-TC0052 |
| Product Type | Human Pancreas Cancer Cell Lines |
| Cell Type | Epithelial-like |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Adenocarinoma |
| Product Code | AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 |
Utilize AsPC-1 pancreatic cancer line for tumor microenvironment modeling, chemoresistance studies, and metastatic behavior research in vitro.
AsPC-1 is a human epithelial-like pancreatic adenocarcinoma cell line derived from a nude mouse xenograft established with ascitic cells from a 62-year-old female patient with pancreatic adenocarcinoma and ascitic metastasis. The cells exhibit adherent growth and retain epithelial morphology. The original characterization demonstrated abundant mucin production and expression of carcinoembryonic antigen (CEA) and human pancreas cancer-associated antigen. AsPC-1 also carries a KRAS p.G12D mutation and has demonstrated tumorigenicity in athymic nude mouse models, supporting its use as an in vitro and in vivo model for pancreatic cancer research.
| Product Code | AsPc-1; Aspc-1; ASPC-1; As-PC1; ASPC1; AsPC1; Aspc1; AsPc1 |
| Species | Human |
| Cat.No | ABC-TC0052 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial-like |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
AsPC-1 cells can be used for pancreatic cancer research involving tumor growth, invasion, metastasis, and drug response. The cell line has been used as an experimental model for investigating pancreatic adenocarcinoma biology and evaluating responses to anticancer agents, including studies of gemcitabine sensitivity and resistance. AsPC-1 can also be incorporated into appropriate xenograft studies to investigate tumorigenicity, tumor growth, and metastatic behavior in vivo. The specific phenotype and metastatic outcome of xenograft models depend on the implantation site and experimental design.
AsPC-1 supports research focused on pancreatic adenocarcinoma, KRAS-mutant pancreatic cancer biology, epithelial-mesenchymal transition (EMT), chemoresistance, tumor invasion, and metastasis. The cell line carries a documented KRAS p.G12D mutation together with additional genetic alterations reported in pancreatic cancer cell-line characterization datasets. AsPC-1 has also been used in studies investigating EMT-associated phenotypes, migration and invasion, and mechanisms related to gemcitabine response and chemoresistance.
Cell Recovery(Thaw and recover the cryopreserved AsPC-1 cells under appropriate culture conditions.) → Cell Culture(Maintain the adherent cells in the recommended complete growth medium and culture conditions.) → Cell Expansion(Expand the cells to obtain sufficient material for the planned experiment while maintaining appropriate culture conditions.) → Experimental Treatment(Expose AsPC-1 cells to candidate compounds, genetic interventions, or other experimental conditions according to the study design.) → Phenotypic Assessment(Evaluate cell viability, proliferation, morphology, migration, invasion, or other relevant cellular responses.) → Molecular Analysis(Analyze gene expression, signaling pathways, genetic alterations, biomarkers, or other molecular characteristics associated with pancreatic cancer.) → Drug Response Analysis(Assess treatment responses and investigate potential mechanisms of drug sensitivity or resistance.) → In Vivo Modeling(When required, use AsPC-1 cells in appropriate xenograft models to investigate tumor growth or metastatic behavior.)
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
