B6129SF2/J Mouse Lung Fibroblasts

Description

B6129SF2/J Mouse Lung Fibroblasts are primary cells isolated from the lung tissue of B6129SF2/J mice, a hybrid strain widely used in respiratory disease research and fibroblast tissue research in B6129SF2/J mice. These fibroblasts play a vital role in maintaining extracellular matrix homeostasis and participate in wound healing, inflammation, and tissue remodeling. In vitro, they display a spindle-shaped morphology and adherent growth properties. Studies have demonstrated that lung fibroblasts contribute to the progression of pulmonary fibrosis by producing excessive collagen and fibronectin in response to profibrotic signals like TGF-β1. Expression of mesenchymal markers such as vimentin and α-smooth muscle actin is confirmed by immunocytochemistry under profibrotic conditions. They are cryopreserved at early passages to retain phenotypic fidelity Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.