For research use only
| Cat No. | ABC-TC0085 |
| Product Type | Human Breast Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Ductal Cancer |
| Product Code | Bt-474; BT474 |
BT-474 breast tumor cells show ER, PR, HER2 expression; aneuploid; tumorigenic in mice; perfect for hormone-responsive breast cancer research.
BT-474 is a human breast ductal carcinoma cell line that was originally isolated from the breast tissue of a 60-year-old Caucasian female patient with invasive ductal carcinoma. BT-474 exhibits epithelial-like, adherent/patchy morphology, growing in compact, patchy, multi‑layered colonies that rarely become fully confluent. The line is highly aneuploid with a modal chromosome number of ~55 and a hypertetraploid karyotype commonly ranging 91–111 chromosomes. These cells robustly expresses estrogen receptor (ER⁺), progesterone receptor (PR⁺), and HER2/neu (ErbB2⁺) and carries a TP53 mutation. BT-474 is tumorigenic in nude mice. These characteristics make it a powerful model for studying hormone-responsive breast cancer.
| Product Code | Bt-474; BT474 |
| Species | Human |
| Cat.No | ABC-TC0085 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Ductal Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Breast Cancer Cell Lines |
The BT-474 cell line finds valuable applications in preclinical breast cancer research, offering a direct link to real patients with matching genetic profiles. This model proves indispensable in drug discovery endeavors, facilitating the development of innovative targeted treatments for breast cancer. Its utilization spans from investigating small molecules and antibodies to refining cell-based therapies, enhancing the prospects of advancing effective interventions for breast cancer patients.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
