C57BL/6 Mouse Aortic Fibroblasts

Description

C57BL/6 Mouse Aortic Fibroblasts are isolated from the aortic tissue of C57BL/6 mice and represent a specialized population of mouse fibroblasts within the vascular wall. Morphologically, these cells display a spindle-shaped to polygonal form and grow adherently, forming monolayers in culture. As vascular-derived fibroblasts, they express the marker vimentin. These fibroblasts regulate the mechanical tension, inflammatory responses, and tissue repair of the vascular wall by secreting ECM components and cytokines (e.g., TGF-β, IL-6). They play a pivotal role in the pathogenesis of diseases such as atherosclerosis, hypertension, and vascular fibrosis. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.