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Primary Cells

C57BL/6 Mouse Bone Marrow Macrophages

  • For research use only

Cat No.

ABC-TC3171
Product Type

Mouse Primary Cells
Cell Type

Macrophage
Species

C57BL/6 Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Normal
Storage

Liquid Nitrogen

Mouse Bone Marrow Macrophages are derived from the tibias and femurs of pathogen-free laboratory adult mice.

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  • C57BL/6 Mouse Bone Marrow Macrophages
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | C57BL/6 Mouse Bone Marrow Macrophages

Description

C57BL/6 Mouse Bone Marrow Macrophages are primary cells isolated from the tibias and femurs of pathogen-free laboratory mice and serve as an ideal model for studying hematopoietic regulation in C57BL/6 mice. Following primary culture, these cells are cryopreserved. These specialized macrophages play a dual role in maintaining the hematopoietic niche through supportive signaling and secretion of key regulatory factors (CXCL12, SCF, IL-6), while also orchestrating bone remodeling via osteoclast regulation. Their dysfunction is linked to myelodysplastic syndromes, osteoporosis, and chemotherapy-induced bone marrow suppression. C57BL/6 Mouse Bone Marrow Macrophages are characterized using antibodies against CD11b and F4/80. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

C57BL/6 Mouse Bone Marrow Macrophages, C57BL/6 BMM, B6 BM Macrophages, C57BL6 BM-Macs
Species

C57BL/6 Mouse
Cat.No

ABC-TC3171
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Macrophage
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • C57BL/6 Mouse Bone Marrow Macrophages serve as a powerful in vitro model to study hematopoietic niche dysfunction in disease conditions such as chemotherapy-induced bone marrow suppression. For example, by analyzing their regulatory pathways in CXCL12/SCF secretion and VCAM-1-mediated HSC anchoring, this approach provides insights into the physiological maintenance of hematopoiesis and pathological bone marrow failure mechanisms, facilitating the development of targeted niche-repair therapies.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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