C57BL/6 Mouse Embryonic Cardiac Endothelial Cells

Description

C57BL/6 Mouse Embryonic Cardiac Endothelial Cells are primary cells isolated from the heart tissue of pathogen-free laboratory mice during embryonic development. They primarily reside in the endocardium and intramyocardial vasculature. Following primary culture, these cells are cryopreserved. C57BL/6 Mouse Embryonic Cardiac Endothelial Cells are essential models for maintaining cardiovascular integrity in C57BL/6 embryos and orchestrating heart development by driving endocardial cushion formation and valve morphogenesis via endothelial-to-mesenchymal transition (EndMT). They establish coronary circulation through VEGF-dependent angiogenesis, supply oxygen and nutrients to growing myocardium, and mediate cardiomyocyte signaling via neurotrophic factors. C57BL/6 Mouse Embryonic Cardiac Endothelial Cells are tested for the expression of markers including VE-cadherin and CD31/PECAM-1. Repeated freezing and thawing should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.