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| Product Code | CaLu-6; CALU-6; Calu.6; Calu 6; Calu6; CALU6; CaLu-06 |
| Species | Human |
| Cat.No | ABC-TC0112 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Lung Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
Calu-6 is a human lung adenocarcinoma cell line derived from the pleural effusion of a 61-year-old Caucasian female with anaplastic carcinoma. These epithelial-like, adherent cells form monolayers and exhibit a doubling time of 26–72 hours. Karyotypically, Calu-6 is hypotriploid (modal chromosome number 59), lacks the Y chromosome, and carries 14 marker chromosomes. Genetically, they harbor a heterozygous KRAS codon 61 mutation (p.Gln61Lys), are p53-negative, and show FA-BRCA pathway defects, making them useful in oncogenic and DNA repair studies. Tumorigenic in nude mice, they model poorly differentiated carcinomas and are widely used to investigate tumor suppressors and therapies. Overexpression of S100A6 suppresses proliferation, migration, and invasion, while enhancing apoptosis. Calu-6 cells also endogenously express human renin mRNA, which is upregulated by cAMP analogs—making them ideal for renin regulation studies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
The Calu-6 cell line can be utilized as a model to investigate tumor suppression factors and pathways for potential therapies. It has been instrumental in studying the antiproliferative mechanism of apoptosis and understanding the molecular mechanisms of cytotoxic drugs used in lung cancer treatment. Additionally, Calu-6 contributes to the development of novel agents that target specific intracellular pathways associated with cancer cell properties, aiding the ongoing efforts in developing effective treatments for lung cancer and other types of cancer.
