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Tumor Cell Lines

Clone M-3; Cloudman S91 melanoma

  • For research use only

Cat No.

ABC-TC0140
Product Type

Mouse Melanoma Cell Lines
Cell Type

Epithelial
Species

Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Skin
Disease

Melanoma
Product Code

Cloudman S91 melanoma clone M-3; S91 clone M3; CLONE M3; M3 Clone M-3; Cloudman M3

Mouse (CxDBA)F1 melanoma. Established from a Cloudman S91 melanoma in a male mouse; The cells produce melanin.

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  • Clone M-3; Cloudman S91 melanoma
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Home | Tumor Cell Lines | Animal Tumor Cell Lines | Clone M-3; Cloudman S91 melanoma

Description

Clone M‑3 is a murine melanoma cell line derived from a Cloudman S91 tumor that spontaneously arose in a DBA/2 mouse. These pigmented cells grow as adherent monolayers and exhibit epithelial-like morphology with strong melanin production, making them visually identifiable in culture. Clone M-3 is thus a valuable in vivo model for melanoma and immuno-oncology research. It expresses multiple melanoma-related markers, Pmel (gp100), and Tyr (tyrosinase), and also demonstrates ICAM-1 expression, which supports studies on tumor-immune interactions. These cells are highly tumorigenic in syngeneic DBA/2 mice upon subcutaneous or mammary fat pad implantation, with near-uniform tumor take rates. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from mycoplasma, fungi, yeast, and bacteria.

Product Code

Cloudman S91 melanoma clone M-3; S91 clone M3; CLONE M3; M3 Clone M-3; Cloudman M3
Species

Mouse
Cat.No

ABC-TC0140
Product Category

Tumor Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Skin
Disease

Melanoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Melanoma Cell Lines

Application

  • Clone M‑3 is an ideal syngeneic melanoma model for immuno-oncology and therapeutic efficacy studies, particularly for immune checkpoint inhibitors in DBA/2 mice. Its high tumorigenicity and pigmentation make it suitable for subcutaneous, mammary fat pad, and imaging-based tumor models. The line’s expression of melanoma differentiation antigens (tyrosinase, gp100, TRP-2) and MHC I supports tumor immunogenicity and immune profiling assays. Clone M‑3 also enables testing of EGFR-targeted therapies when engineered to express human EGFR, preserving tumor growth and receptor function in vivo. Its stable adherent phenotype supports in vitro drug screening, signal transduction analysis, and flow cytometry-based characterization.

Citation

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