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B16/BL6

Product Name

B16/BL6

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Product Code

B16-BL6; B16 BL6; B16BL6; B16BL-6; BL6; BL-6; B16-F10-BL6

Cat.No

ABC-TC0060

Species

Mouse

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

The B16-BL6 cell line is a murine melanoma model derived from B16-F10, known for its tissue-invasive property. Clones derived from B16-BL6 exhibit high metastatic potential and elevated levels of hormonally-stimulated adenylate cyclase, confirming the connection between hormonal responsiveness and metastasis. These melanoma cells are poorly immunogenic, similar to other spontaneously arising tumors, and express low levels of major histocompatibility complex (MHC) antigens. Additionally, B16-BL6 cells release inhibitory factor(s) that affect the active pump activity in isolated lymph vessels.

 

Why choose B16-BL6 from AcceGen?

B16-BL6 from AcceGen is the ideal choice due to its sterile nature and ability to incubate under standardized conditions. With high quality and viability, it boasts an advanced cryopreservation technique ensuring optimal preservation. Additionally, AcceGen employs rigorous quality control measures, further enhancing the reliability and consistency of the B16-BL6 cell line.

Disease

Melanoma

Source Organ

Skin

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Clement, E., Lazar, I., Attané, C., Carrié, L., Dauvillier, S., & Ducoux‐Petit, M. et al. (2020). Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells. The EMBO Journal, 39(3). https://doi.org/10.15252/embj.2019102525

Application

FOR RESEARCH USE ONLY

The B16-BL6 cell line serves as a valuable tool for studying various aspects of melanoma, including metastasis, hormonal regulation, and tumor immune evasion. Additionally, this cell line finds application in assessing the efficacy and pharmacodynamics (PD) of anti-cancer therapeutics. Researchers can utilize the B16-BL6 model in both subcutaneous and metastatic settings, allowing for the investigation of tumor growth, response to treatments, and the development of novel therapeutic strategies. Its availability in different models enhances its versatility and utility in preclinical studies focused on melanoma research and drug development.

Growth Conditions

37 ℃, 5% CO2

Product Type

Mouse Melanoma Cell Lines

Product Image

b16 bl6 cell lineAcceGen product b16 bl6 cell line

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