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| Product Code | DMS-273; DMS273 |
| Species | Human |
| Cat.No | ABC-TC0214 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pleural Fluid |
| Disease | Lung Small Cell Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
DMS-273 is a valuable cell line for studying small-cell lung cancer (SCLC), an aggressive cancer known for its high metastatic potential. Transplanting DMS-273 into the lungs of nude mice creates a metastasis model and facilitates the testing of drugs or inhibitors. For instance, DMS-273 exhibits amplification of the SETDB1 gene, resulting in the overexpression of SETDB1 protein, enhancing cell invasion in lung carcinoma. This finding provides insights into the potential application of SETDB1 inhibitors as new therapies. Similarly, in DMS-273, inhibitors or siRNA targeting signaling pathways associated with cancer progression and invasion can be tested to impede the progression of SCLC.
