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Tumor Cell Lines

EoL-1 cell

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Cancer; Lifespan: infinite. Eosinophilic leukemia. Differenciate by n-butylate treatment.
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Product Code

EOL-1; EOL1; EoL-1-cell; EoL-1 cell; AML-EOL-1

Species

Human

Cat.No

ABC-TC440S

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Lymphoblast

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Blood

Storage

Liquid Nitrogen

Product Type

Human Leukemia Cell Lines

Description

EoL-1
EoL-1 is a human acute myeloid leukemia (AML) cell line derived from the peripheral blood of a 33-year-old male patient diagnosed with eosinophilic AML. This cell line exhibits myeloblast-like morphology and grow in suspension culture, with a doubling time of approximately 60 hours under standard conditions. Karyotypic analysis reveals a characteristic KMT2A (MLL) partial tandem duplication, a hallmark genetic alteration in specific AML subtypes. EoL-1 cells express eosinophilic lineage surface markers, including CD11b, CD13, and CD33, and exhibit interleukin-5 (IL-5) sensitivity, enabling their utility in studying eosinophil differentiation pathways .This cell line shows susceptibility to HIV-1 infection, further broadening their utility in modeling host-pathogen interactions. EoL-1 is tumorigenic and serves as a critical model for investigating AML pathophysiology, hematopoietic development, and drug screening.
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Citation

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Application

  • EoL-1 serves as a valuable model in hematological malignancy research, especially in studies focusing on eosinophilic acute myeloid leukemia (AML) and KMT2A-rearranged leukemias. Its IL-5 responsiveness and eosinophilic marker expression allow for in-depth analysis of eosinophil lineage commitment and differentiation mechanisms. This cell line is also instrumental in evaluating chemotherapeutic agents targeting leukemic blasts or eosinophil differentiation pathways, enabling high-throughput drug efficacy and cytotoxicity screening. Additionally, EoL-1 provides a robust in vitro for exploring virus-host interactions, offering insights into the interplay between hematopoietic malignancies and viral pathogenesis.

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