For research use only
| Cat No. | ABC-TC0287 |
| Product Type | Human Lung Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
HARA cell line is a human lung squamous carcinoma model widely used for tumor biology, metastasis studies, and therapeutic drug development research.
HARA is a human squamous cell lung carcinoma cell line that was originally isolated from the malignant pleural effusion of a 57-year-old East Asian male patient with squamous cell lung carcinoma (SCLC). The cells display adherent, epithelial-like morphology and exhibit a transition to fibroblast-like appearance upon adaptation in bone microenvironments. These cells exhibit a distinctive trait of producing high levels of parathyroid hormone-related protein (PTHrP), contributing to osteolytic activity and hypercalcemia in vivo. HARA cells maintain typical squamous markers including high expression of p63, cytokeratin 5/6, and DSG3 (desmoglein-3), while showing common molecular alterations of lung SCC such as TP53 mutations and SOX2 amplification. The line exhibits chromosomal instability consistent with aggressive tumor behavior. It is tumorigenic in immunodeficient mouse models, forming both subcutaneous and bone metastatic lesions following intracardiac inoculation. HARA’s metastatic origin and well-differentiated phenotype make it particularly valuable for studying advanced-stage disease progression and tumor microenvironment interactions.
| Species | Human |
| Cat.No | ABC-TC0287 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
The HARA cell line is valuable for its unique expression of both PTHrP and IL-1, making it an important model for studying their interplay in inducing hypercalcemia. This dual expression allows researchers to explore the mechanisms behind bone resorption and hypercalcemia development. Additionally, HARA cells are particularly suited for investigating bone metastasis, as IL-1 contributes to bone resorption while PTHrP plays a critical role in the formation and progression of bone metastases. Together, these features make the HARA cell line a powerful tool for understanding the complex biology of bone-related cancer complications.
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