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| Species | Human |
| Cat.No | ABC-TC0287 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
HARA is a human squamous cell lung carcinoma cell line that was originally isolated from the malignant pleural effusion of a 57-year-old East Asian male patient with squamous cell lung carcinoma. HARA exhibits epithelial-like morphology and adherent culture properties. These cells exhibit a distinctive trait of producing notable quantities of parathyroid hormone-related protein (PTHrP), as evidenced by both PTHrP RNA transcripts and substantial PTHrP secretion. Alongside PTHrP, the cell culture medium demonstrates a notable presence of interleukin 1 (IL-1).
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The HARA cell line’s significance lies in its potential applications, particularly in elucidating the interplay between PTHrP and IL-1 for hypercalcemia induction, owing to its expression of both factors. Moreover, its suitability for investigating bone metastasis is underscored by IL-1’s bone-resorbing activity and PTHrP’s pivotal role in bone metastasis formation, offering valuable insights into these complex biological processes.
