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| Species | Human |
| Cat.No | ABC-TC0403 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
HCT-8 is a human colorectal adenocarcinoma cell line that was originally isolated from the colon of a 67-year-old Caucasian male patient with ileocecal adenocarcinoma. HCT-8 exhibits epithelial-like morphology and adherent culture properties. Immunoperoxidase staining confirmed that HCT-8 cells are positive for cytokeratin expression. This cell line is tumorigenic.
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The HCT-8 cell line is a valuable tool in both cancer and toxicology research. It is widely used to study drug resistance and to elucidate the mechanisms underlying chemoresistance. These cells also support investigations into cell death pathways, including apoptosis and necrosis. Notably, HCT-8 cells are used in the construction of compartmentalized three-dimensional (3D) intestinal models, offering an alternative culture system for continuous cell propagation and enabling detailed studies of gastrointestinal diseases and drug responses.
