HighQC Human iPSC-Derived GABAergic neurons PSEN1 M146L/WT

Description

HighQC Human iPSC-Derived GABAergic neurons PSEN1 M146L/WT are human iPSC-derived GABAergic neurons generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for Alzheimer’s disease research in central nervous system biology. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a heterozygous PSEN1 M146L missense mutation paired with one wild-type (WT) allele and represents a familial Alzheimer’s disease (FAD)-associated presenilin-1 mutation model in vitro, without recapitulating full clinical phenotypes. They exhibit functional characteristics of GABAergic neurons. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.