HighQC Human iPSC-Derived Motor Neurons TDP-43 M337V/M337V

Description

HighQC Human iPSC-Derived Motor Neurons TDP-43 M337V/M337V are human iPSC-derived motor neurons generated from a human iPSC line originally derived from adult skin fibroblasts. These cryopreserved cells provide a defined in vitro model for amyotrophic lateral sclerosis (ALS) and TDP-43-associated neurodegenerative disease research. The cells are produced through a directed differentiation protocol to support reproducible lineage-specific experimental systems. This line carries a homozygous TDP-43 M337V missense mutation on both alleles, modeling TDP-43 proteinopathy relevant to familial ALS/frontotemporal dementia (FTD), without implying a fixed clinical phenotype. They retain neuronal lineage characteristics associated with motor neuron models. Quality control testing includes sterility assessment and lineage characterization by protein expression and gene expression assays, where applicable. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.