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| Product Code | HL 60; HL.60 HL60; Human Leukemia-60 |
| Species | Human |
| Cat.No | ABC-TC0389 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Myeloblastic |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Acute Promyelocytic Leukemia |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
HL-60 is a human promyeloblast cell line originally isolated from the peripheral blood of a 36-year-old Caucasian female diagnosed with acute promyelocytic leukemia (APL). HL-60 exhibits lymphoblast-like morphology and grow in suspension. HL-60 has a near-triploid karyotype, typically ranging from 64 to 78 chromosomes. This cell line expresses key myeloid differentiation markers such as CD33 and CD11b but lacks the PML-RARA fusion protein that is commonly present in classical APL cell. HL-60 is tumorigenic in SCID mice, where it can form granulocytic sarcomas following subcutaneous injection. HL-60 possess the capacity to differentiate into granulocyte- or monocyte-like lineages in response to chemical inducers such as retinoic acid (ATRA) or dimethyl sulfoxide (DMSO).
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HL-60 cells are a widely used model in hematological and cancer research. They are instrumental in studying leukemic cell proliferation, differentiation, apoptosis, and the mechanisms of myeloid lineage commitment. Their responsiveness to various differentiation agents makes them an ideal platform for evaluating the efficacy of anticancer drugs and chemotherapy efficiency. Additionally, HL-60 cells are valuable for investigating phagocytosis, calcium signaling, and the production of extracelluler vesicles (EV). Furthermore, HL-60 cells serve as an essential model system for immunological research and vaccine development, serving as a versatile in vitro system for elucidating cellular and molecular pathways in myeloid biology.
