Human Coronary Art Sm Mus Cells-Diabetic Type II

Description

Human Coronary Artery Smooth Muscle Cells-Diabetic Type II (HCASMC‑DM2) are isolated from Type 2 diabetic donors and cryopreserved at early passage to maintain high viability. HCASMC-DM2 cells typically exhibit a spindle-shaped morphology and grow as a monolayer under standard culture conditions. They express key smooth muscle markers including alpha-smooth muscle actin (α-SMA) and calponin. In Type 2 Diabetes, vascular smooth muscle cells (VSMCs) exhibit increased proliferation, adhesion, migration, and altered mechanical properties like reduced stiffness and enhanced traction force—contributing to accelerated atherosclerosis, restenosis, and vascular remodeling. Diabetic Type 2 HCASMC primary cells provide a robust in vitro model for studying diabetic macro- and microvascular pathologies. To preserve functional integrity, avoid repeated freeze-thaw cycles during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.