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Transfected Stable Cell Lines

Human FGFR3 (V555M) NIH/3T3 Cell Line

  • For research use only

Cat No.

ABC-X0023C
Product Type

Overexpression Stable Cell Lines
Cell Type

Fibroblast
Species

Human
Host Cell

NIH/3T3
Source Organ

Embryo
Disease

Normal
Storage

Liquid Nitrogen

The FGFR3 (V555M) NIH/3T3 cell line is an ideal platform for studying FGFR3 activating mutations, facilitating the development and validation.

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  • Human FGFR3 (V555M) NIH/3T3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR3 (V555M) NIH/3T3 Cell Line

Description

Human FGFR3 (V555M) NIH/3T3 Cell Line is a genetically engineered model derived from selected murine NIH/3T3 parental cell line based on customers’ requirement. FGFR3 (V555M) NIH/3T3 mutant cell line is generated by stable integration of exogenous human FGFR3 gene harboring the V555M point mutation into NIH/3T3 host cells using our optimized transduction of lentiviral vectors.
Target
FGFR3 encodes fibroblast growth factor receptor 3, a transmembrane tyrosine kinase involved in cell differentiation, proliferation, and survival. The V555M mutation occurs in the kinase domain and has been reported as an activating mutation associated with oncogenic transformation. FGFR3 alterations are implicated in multiple malignancies including bladder cancer, multiple myeloma, and cervical cancer. AcceGen offers generation of stable overexpression and mutation-specific cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0023C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The FGFR3 (V555M) NIH/3T3 Cell Line serves as a powerful tool to investigate FGFR3-mediated signaling and oncogenesis. This model enables mechanistic studies of constitutive kinase activation, MAPK/ERK pathway upregulation, and response to FGFR-targeted inhibitors. It is utilized for preclinical drug screening and validation of precision oncology therapeutics.

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Inquiring Human FGFR3 (V555M) NIH/3T3 Cell Line

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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