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Primary Cells

Human Glomerular Microvascular Endothelial Cells

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Primary Human Glomerular Microvascular Endothelial Cells were initiated by decapsulated glomeruli isolated from normal human kidney cortical tissue. These cells were originated using Complete Serum-Free Medium Kit With AcceSup™, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells. This vial will initiate a Passage […]
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Home | Primary Cells | Human Primary Cells | Urinary System Primary Cells | Human Glomerular Microvascular Endothelial Cells
Species

Human
Cat.No

ABC-TC3631
Quality Control

All cell lots are tested negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi and other pathogens.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Glomerular
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Renal Cells
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Description

Human glomerular microvascular endothelial cells (HGMECs), originally isolated from th glomerular microvasculature of normal human kidney tissue obtained from healthy adult donors, characterized by their fenestrated morphology and tight monolayer growth pattern under standard culture conditions. HGMECs regulate vasomotor tone, blood coagulation, and selective leukocyte trafficking. The presence of fenestrations (approximately 50–100 nm) allows selective permeability, contributing to their specialized filtration function. HGMECs exhibit normal diploid karyotypes and express typical endothelial markers such as CD31 (PECAM-1), von Willebrand Factor (vWF), and VE-Cadherin (CD144), confirmed via immunocytochemistry and flow cytometry. The cells are collected from disease-free tissues and are provided at low passage (P3–P6) to preserve their physiological characteristics and proliferative capacity. While HGMECs are capable of multiple passages under optimized culture conditions, they are not immortalized and have limited replicative lifespan.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Glomerular Microvascular Endothelial Cells (HGMECs) provide a physiologically relevant in vitro model for studying the function and pathophysiology of glomerular endothelial cells. They are particularly useful for investigating mechanisms of endothelial permeability, inflammation, and vascular regulation within the glomerulus. HGMECs enable researchers to explore cellular crosstalk and interactions that maintain glomerular structure and function when co-cultured with podocytes and mesangial cells. Considering their vital role in glomerular homeostasis, HGMECs serve as a valuable research tool for studying the progression of kidney diseases and for developing therapeutic strategies aimed at treating chronic kidney disease or restoring filtration function after renal injury.

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