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Primary Cells

Human Kidney Podocyte Cells

  • For research use only

Cat No.

ABC-H0004Y
Product Type

Renal Cells
Cell Type

Podocyte
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Storage

Liquid Nitrogen

Human Kidney Podocyte Cells are isolated from kidney cortex via glomerular digestion and support studies of glomerular filtration and disease.

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  • Human Kidney Podocyte Cells
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Home | Primary Cells | Human Primary Cells | Urinary System Primary Cells | Human Kidney Podocyte Cells

Description

Human Kidney Podocyte Cells are primary epithelial-like cells isolated from the glomeruli of healthy human kidney tissue and cryopreserved at low passage numbers to preserve their native characteristics. As integral components of the glomerular filtration barrier, podocytes form interdigitating foot processes connected by slit diaphragms, which regulate selective plasma filtration and prevent proteinuria. In vitro, they display a unique, highly specialized shape characterized by a cell body, primary processes, and pedicels. They exhibit vesicular trafficking activity associated with filtration function. Podocytes express characteristic markers including nephrin, podocin, WT1, and synaptopodin, confirmed by immunocytochemistry and gene expression analysis. Podocyte injury or loss is implicated in glomerular diseases such as focal segmental glomerulosclerosis, minimal change disease, and diabetic nephropathy, making them a critical model for studying kidney disease mechanisms and therapeutic screening in renal research.

Product Code

Human Kidney Podocyte Cells, HKPCs, Human Podocytes, Human Kidney Podocyte Cells
Species

Human
Cat.No

ABC-H0004Y
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Podocyte
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Renal Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human kidney podocytes provide a reliable in vitro model for investigating glomerular pathophysiology. These cells are widely used in toxicology assays to evaluate nephrotoxicity of compounds and to study drug metabolism and targeted therapeutic effects on kidney function. As a platform for drug discovery, cultured podocytes facilitate research into glomerular diseases such as focal segmental glomerulosclerosis and diabetic nephropathy. Additionally, they support mechanistic studies of the glomerular filtration barrier, advancing understanding of renal function and enabling the development of novel interventions for kidney disorders. This in vitro system thus serves as a valuable tool in both basic renal biology and translational nephrology research.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Xia J, Huang Y, Ma M, Liu F, Cao B. Downregulating lncRNA MIAT attenuates apoptosis of podocytes exposed to high glucose. Acta Diabetologica. 2023;61(4):451-460. doi:10.1007/s00592-023-02213-w

Frequently Asked Questions

  • What is the cell isolation method used for Human Kidney Podocyte Cells?

    Fresh renal cortical tissue is obtained and minced, followed by enzymatic digestion with collagenase to release the cells. The target cells are then isolated and purified using differential attachment methods. Immunofluorescence staining for PCK expression is performed to identify the cells.

  • What are podocytes / are podocytes epithelial cells?

    Podocytes are specialized epithelial cells in the kidney glomerulus. They wrap around capillaries and form slit diaphragms, playing a critical role in the filtration barrier and maintaining glomerular structure and function..

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