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Primary Cells

Human Oligodendrocyte Progenitor Cells

  • For research use only

Cat No.

ABC-TC3732
Product Type

Nervous Cells
Cell Type

Oligodendrocyte
Species

Human
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Storage

Liquid Nitrogen

Human OPCs from adult white matter, express NG2, PDGFRα, O4, support remyelination, ideal for MS and neural repair studies, BSL-1 and pathogen-free.

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  • Human Oligodendrocyte Progenitor Cells
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Oligodendrocyte Progenitor Cells

Description

Human Oligodendrocyte Progenitor Cells (OPCs) are glial precursor cells in the central nervous system (CNS). They originate from neuroepithelial stem cells during the embryonic development. Morphologically, OPCs are bipolar or multipolar with slender and highly dynamic processes. Typical markers of OPCs include PDGFRα, NG2, and SOX10. The core function of OPCs is to generate myelinating oligodendrocytes in CNS. Through differentiation into mature oligodendrocytes, OPCs produce myelin—a lipid-rich membrane that wraps around neuronal axons. This myelin sheath serves two critical functions including providing electrical insulation that prevents current leakage and enabling saltatory conduction where action potentials jump between nodes of Ranvier, significantly accelerating neural signal transmission. Therefore, the OPC-oligodendrocyte-myelin axis is essential for maintaining efficient and high-fidelity electrical communication in the CNS. Oligodendroglial cells derived from OPCs not only support axonal conduction but also contribute to metabolic support and overall homeostasis within the central nervous system.

Product Code

HOPCs
Species

Human
Cat.No

ABC-TC3732
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Oligodendrocyte
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Oligodendrocyte Progenitor Cells can be used to establish an in vitro myelination model, simulating neuron-oligodendrocyte interactions through a three-dimensional culture system. This provides an ideal platform for studying the mechanism of myelination formation and the pathology of demyelinating diseases. These cells can also be used to screen pro-myelination compounds.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What is the recommended medium for expanding Human Oligodendrocyte Progenitor Cells?

    AcceGen’s expansion medium (ABM-TM3732) is recommended for optimal growth and proliferation.

  • Which medium should be used for differentiating these cells?

    Use AcceGen’s differentiation medium (ABM-TX3732) to promote the differentiation of Human Oligodendrocyte Progenitor Cells.

  • What are the typical applications of Human Oligodendrocyte Progenitor Cells in research?

    These cells are used in studies of myelination, neurodegenerative diseases, and CNS repair mechanisms.

  • What storage conditions are necessary for maintaining cell viability?

    Cells should be stored in liquid nitrogen immediately upon receipt to ensure viability.

  • What precautions should be taken while handling Human Oligodendrocyte Progenitor Cells?

    Handle cells under sterile conditions using appropriate biosafety protocols to avoid contamination and ensure safety.

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Inquiring Human Oligodendrocyte Progenitor Cells

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
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