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Primary Cells

Human Skeletal Muscle Microvascular Endothelial Cells

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Human Primary Skeletal Muscle Microvascular Endothelial Cells are isolated from human skeletal muscle tissue. Human Primary Skeletal Muscle Microvascular Endothelial Cells from Cell Biologics display typical cobblestone with large dark nuclei appearance under light microscopy. Cells are tested for expression of endothelial cell marker using antibody CD31.
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Home | Primary Cells | Human Primary Cells | Motion System Primary Cells | Human Skeletal Muscle Microvascular Endothelial Cells
Species

Human
Cat.No

ABC-H0025Y
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Skeletal Muscle
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Skeletal Muscle Cells
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

 

Description

Human Skeletal Muscle Microvascular Endothelial Cells are isolated from human skeletal muscle tissue and line the inner surface of microvascular capillaries within skeletal muscles. They serve as a barrier between circulating metabolites and tissues, playing a key role in regulating nutrient exchange, immune cell migration, and maintaining vascular integrity. These cells are characterized by their ability to uptake acetylated low-density lipoprotein (ac-LDL), adenosine, and their capacity to produce nitric oxide (NO), which is vital for vascular tone regulation. Additionally, they are commonly identified by the expression of endothelial cell marker CD31. Human Skeletal Muscle Microvascular Endothelial Cells are cryopreserved to maintain high viability and functionality, and repeated freeze-thaw cycles should be avoided to ensure optimal performance in research.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human primary skeletal muscle microvascular endothelial cells serve as an ideal model for in vitro studies of the biology and biochemistry of endothelial cells. Theyare used in various research applications, including endothelial dysfunction, skeletal muscle regeneration, and interactions with other skeletal muscle cells, like satellite cells.

Frequently Asked Questions

  • What are Human Skeletal Muscle Microvascular Endothelial Cells (HSkMECs)?

    Human Skeletal Muscle Microvascular Endothelial Cells (HSkMECs) are specialized cells derived from the microvasculature of human skeletal muscle tissue. They are pivotal in studying vascular functions and pathologies within skeletal muscle.

  • What are the key characteristics of HSkMECs？

    HSkMECs exhibit properties such as the expression of endothelial markers (e.g., CD31, VE-cadherin), the ability to form capillary-like structures in vitro, and responsiveness to angiogenic factors.

  • What are the primary research applications of HSkMECs?

    HSkMECs are used in studies focusing on muscle regeneration, angiogenesis, diabetes-related vascular complications, and muscle perfusion. They are used in research to provide insight into the microvascular functions and pathologies associated with skeletal muscle. Researchers use HSkMECs to investigate the mechanisms by which high glucose levels and insulin resistance affect microvascular endothelial function, offering a model to study the vascular complications often seen in diabetic patients.

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