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| Product Code | IST-MES2; IST-MES-2; ISTMES2; IstMes2 |
| Species | Human |
| Cat.No | ABC-TC0459 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Pleural Epithelioid Mesothelioma |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
IST MES2 is an epithelial-like cell that was originally isolated from the pleural effusion of a 71-year-old, Caucasian male patient with malignant pleural mesothelioma (MPM). IST MES2 exhibits epithelial-like morphology and adherent culture properties. IST MES2 cell are able to express stemness markers such as CD24, ABCG2 and OCT4 that it can be utilised in the research for mechanisms of MPM drug resistance and metastasis. In certain culture condition, IST MES2 cell can growth as a non-adherent spherical clusters to study the tumor infiltration cells in mesothelioma.
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The IST MES2 cell line holds significant applications in various aspects of malignant pleural mesothelioma (MPM) research. It serves as an essential tool to highlight the biology of MPM and evaluate the efficacy of new antiproliferative compounds. Additionally, IST MES2 is a valuable cell model for identifying novel targets for innovative pharmacological therapy against MPM. Moreover, it aids in proposing molecular pathways for potential pharmacological targets, paving the way for personalized medicine in MPM patients. Furthermore, the cell line allows investigation into the development of resistance to receptor-induced cell death in malignant mesothelial cells, providing insights into therapeutic challenges and potential solutions for MPM treatment.
