KLN205/STAT5 Reporter (Luc) Stable Cell Line

Description

KLN205/STAT5 Reporter (Luc) Stable Cell Line is a bioluminescent reporter model derived from murine lung squamous carcinoma KLN205 cells, featuring stable integration of a luciferase (Luc) gene under the control of STAT5-responsive promoter elements. This engineered system enables sensitive, quantitative monitoring of STAT5 pathway activation via luciferase activity, while retaining the epithelial morphology and tumorigenic features of parental KLN205 cells. The luciferase reporter provides a robust readout of STAT5 dynamics in response to cytokines such as IL-2 and GM-CSF, or to pharmacological modulators, making it ideal for high-throughput screening and JAK-STAT mechanism studies. Applications include drug discovery targeting STAT5, analysis of cytokine signaling networks, and functional studies of tumor–microenvironment interactions. All cells are rigorously quality-controlled and confirmed negative for mycoplasma, fungi, yeast, and bacteria.