For research use only
| Cat No. | ABC-TC0549 |
| Product Type | Human Leukemia Cell Lines |
| Cell Type | Lymphocyte |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Product Code | KU812; KU-812; KU.812; KU 812 |
Chronic myeloid leukemia (CML). Dt = 20 - 30hr, colony formation on soft agar = 30 - 50%
KU812 is a human chronic myelogenous leukemia (CML) tumor cell line established from the peripheral blood of a 38‑year‑old male patient in blast crisis of CML, and it contains at least one Philadelphia chromosome (BCR‑ABL), a key driver of CML pathogenesis. The cells grow in suspension with lymphoblast‑like/immature basophil precursor morphology and exhibit features such as metachromatic granules and histamine synthesis, reflecting basophilic differentiation potential in vitro. KU812 has been shown to differentiate under specific conditions toward myelomonocytic and basophilic phenotypes, and can be induced to express lineage‑associated markers such as FcεRI when cultured with cytokines like IL‑4, indicating multilineage responsiveness. These molecular and phenotypic characteristics make KU812 useful for studying hematopoietic differentiation mechanisms and CML biology. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV‑1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
| Product Code | KU812; KU-812; KU.812; KU 812 |
| Species | Human |
| Cat.No | ABC-TC0549 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphocyte |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Blood |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
KU812 is used as an in vitro model of human CML and myeloid blast crisis to investigate hematopoietic differentiation, basophil biology, and leukemic signaling pathways. It supports studies of cytokine‑mediated modulation of differentiation, histamine release and Fc receptor expression, and serves in comparative functional analyses with other leukemia lines in drug response profiling and molecular oncology research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
