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MOLM-13

  • BSL

    1

  • 1093
Established from the peripheral blood.
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Home | Tumor Cell Lines | Human Tumor Cell Lines | MOLM-13
Product Code

MOLM13; Molm13; Molm 13
Species

Human
Cat.No

ABC-TC517S
Product Category Tumor Cell Lines
Size/Quantity

1 vial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Blood
Disease

Acute Myeloid Leukemia
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Human Leukemia Cell Lines

Description

MOLM-13
MOLM-13 is a human leukemia cell line derived from the peripheral blood of a 20-year-old Japanese male diagnosed with relapsed acute myeloid leukemia (AML), FAB subtype M5a. The cells display monoblast-like morphology with round to oval shape and grow in suspension culture using RPMI-1640 medium with 10% FBS. When stimulated with IFN-γ alone or combined with TNF-α, the cells can differentiate into macrophage-like cells. MOLM-13 carries a complex karyotype, a FLT3-ITD mutation, and the MLL-AF9 (KMT2A-MLLT3) fusion gene. Its immunophenotype includes CD34+, CD15+, CD33+, CD4+, cyCD68+, while negative for CD13, CD14, CD3, and HLA-DR. The cell line is tumorigenic in immunodeficient mice, although metastatic capacity is not well characterized.
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Application

  • MOLM-13 is an important model for studying differentiation and leukemogenesis. For example, used in reverse transcriptase polymerase chain reaction (RT-PCR) analysis, MOLM-13 contains the mRNA of the MLL-AF9 fusion gene, which is a kind of MLL gene rearrangement and related to the leukemia development. MOLM-13 can help identify the genetic profile of human leukemia and identify more genetic markers, such as MLL-AF9 for the diagnosis and prognosis. MLL-rearranged leukemia is hard to treat, MOLM-13 may be used in more scientific research to discover the leukemia mechanisms based on MLL fusions.

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