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| Product Code | MNKCs |
| Species | Mouse |
| Cat.No | ABC-TC5527 |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | NK Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Normal |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Primary Cells |
Mouse NK Cells are isolated from peripheral blood or solid tissues (e.g., spleen, liver) of healthy mice. As mature lymphocytes, these cells exhibit a round-to-oval morphology with irregular extensions and suspension culture properties. Primary mouse NK cells demonstrate limited proliferative capacity and are typically maintained for 1-2 passages to preserve functional integrity. Key functional characteristics include cytotoxicity against targets cells through perforin/granzyme release and cytokine production. They express surface markers CD49b, CD122, NKG2D, and NK1.1+, with subset-specific expression of Ly49 receptors and CD27 correlating with maturation stages (CD11b+CD27+ for mature subsets). Repeated freeze-thaw cycles should be avoided.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Mouse NK cells serve as powerful tools for investigating innate immunity, tumor surveillance, and pathogen defense mechanisms. Their cytotoxic activity makes them ideal for in vitro cytotoxicity assays to evaluate cancer immunotherapy candidates, such as checkpoint inhibitors or CAR-NK strategies. These cells are also employed to study cytokine-driven responses in infection models or autoimmune conditions. Due to limited proliferative capacity, they are best suited for short-term functional assays, drug screening, or mechanistic studies requiring primary cell relevance.
