For research use only
| Cat No. | ABC-TC5527 |
| Product Type | Mouse Primary Cells |
| Cell Type | NK Cell |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Normal |
| Storage | Liquid Nitrogen |
Mouse NK Cells enable cytotoxicity assays, tumor surveillance modeling, and innate immune pathway evaluation in preclinical immuno-oncology studies.
Mouse NK (Natural Killer) Cells are isolated from peripheral blood or solid tissues (e.g., spleen, liver) of healthy mice. As mature lymphocytes, these cells exhibit a round-to-oval morphology with irregular extensions and suspension culture properties. These innate immune lymphocytes play a critical role in early defense against tumors and viral infections through direct cytotoxicity and cytokine production. Key functional characteristics include cytotoxicity against targets cells through perforin/granzyme release and cytokine production. They express classic NK markers CD49b(DX5), CD122(IL-2Rβ), and NK1. 1, with subset-specific expression of Ly49 receptors and CD27 correlating with maturation stages (CD11b⁺ CD27⁺ for mature subsets). Primary mouse NK cells demonstrate limited proliferative capacity in vitro without cytokine support. Repeated freeze-thaw cycles should be avoided. These NK cells maintain native functionality for studies of cancer immunotherapy, viral immunity, and antibody-dependent cellular cytotoxicity (ADCC).
| Product Code | MNKCs |
| Species | Mouse |
| Cat.No | ABC-TC5527 |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | NK Cell |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Normal |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Primary Cells |
Mouse NK cells serve as powerful tools for investigating innate immunity, tumor surveillance, and pathogen defense mechanisms. Their cytotoxic activity makes them ideal for in vitro cytotoxicity assays to evaluate cancer immunotherapy candidates, such as checkpoint inhibitors or CAR-NK strategies. These cells are also employed to study cytokine-driven responses in infection models or autoimmune conditions. Due to limited proliferative capacity, they are best suited for short-term functional assays, drug screening, or mechanistic studies requiring primary cell relevance.
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