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| Product Code | MT2; MT-2J; MT-2Org |
| Species | Human |
| Cat.No | ABC-TC0707 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphoblast |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lymphocyte |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
MT-2 is a human cord T cell line that was originally established by co-cultivation of the peripheral leukocytes from a 45-year-old female T-cell leukemia patient with cord leukocytes from a male infant. MT-2 exhibits lymphoblast-like morphology and semi-adherent culture properties. The stemline karyotype of MT-2 is diploid with a male chromosomal pattern. This cell line displays typical T-cell characteristics, including expression of sheep red blood cells and complement receptors. MT-2 cells are persistently infected with type-C virus particles (ATLV) and are positive for ATL-associated antigens (ATLA), which are specifically recognized by sera from ATL patients.
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The MT-2 cell line exhibits phenotypic and functional characteristics similar to regulatory T cells (Tregs), making it a valuable model for studying Treg biology. These cells harbor HTLV-1 and support HIV replication, providing a platform for investigating virus-host interactions. MT-2 cells are also essential for exploring viral tropism, which is important in clinical decision-making and treatment development for infectious diseases.
