For research use only
| Cat No. | ABC-TC0708 |
| Product Type | Human Leukemia Cell Lines |
| Cell Type | Lymphoblast |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lymphocyte |
| Product Code | MT4 |
The MT-4 cell line is a human T-cell leukemia line widely used in HIV replication, retrovirology, and the antiviral drug discovery research.
MT-4 is a human T-cell leukemia cell line derived from the peripheral leukocytes of a 50-year-old Japanese male patient with adult T-cell leukemia/lymphoma by co-culturing with cells from umbilical cord lymphocytes of another male. The cell line is non-adherent, growing predominantly as lymphoblasts in suspension, with occasional attachment on poly‑L‑lysine–coated surfaces. They exhibit high proliferation rates. MT-4 cells carry endogenous HTLV-1 provirus and produce subviral particles, confirmed by proviral DNA cloning and p24 env analysis. They are highly permissive to HIV-1 infection, including gp41 cytoplasmic tail‑truncated mutants, and display resistance to chemotherapy-induced apoptosis. STR profiling confirms the presence of a Y chromosome. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, fungi, yeast, and bacteria.
| Product Code | MT4 |
| Species | Human |
| Cat.No | ABC-TC0708 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphoblast |
| Growth Mode | Non-adherent or Adherent on Poly-L-lysine Treated Plastic |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lymphocyte |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
MT-4 serves as an essential in vitro model for studying HTLV-1 biology, including viral replication, gene regulation (Tax protein activity), and proviral integration mechanisms. It is highly valuable in HIV-1 research, being uniquely permissive to replication of gp41-mutant and wild-type strains, enabling antiviral drug testing. MT-4 is also used to dissect apoptosis and chemoresistance pathways, particularly in HTLV‑1–infected T cells. Its human leukemic T-cell phenotype makes MT-4 suitable for screening and evaluating novel therapeutics against viral infections and lymphoid malignancies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
