For research use only
| Cat No. | ABC-TC488S |
| Product Type | Human Lung Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Product Code | H292; H-292; NCI-HUT-292; Hut292; NCIH292 |
Mucin-rich NCI-H292 cells from lung mucoepidermoid carcinoma carry CRTC1-MAML2 fusion, ideal for airway mucus regulation and virus-host interaction models.
The NCI-H292 cell line is derived from a cervical lymph node metastasis of pulmonary mucoepidermoid carcinoma (MEC) from a 52-year-old Caucasian male. They exhibit epithelial, polygonal morphology with mucin granules and adherent monolayer growth. Genetically near-diploid (47, XX, ⁺7), it shows microsatellite instability (MSI-low) and harbors hallmark alterations including the CRTC1::MAML2 fusion (from t(11;19)(q21;p13)) and an NF2 frameshift mutation (p. Pro496Thrfs*8). NCI-H292 overexpresses MUC5AC, enabling studies of mucin regulation in airway diseases. These cells are tumorigenic and metastatic in nude mice, and serves as a key model for MEC biology, respiratory virology (e.g., paramyxoviruses), and hepatitis B virus replication, bridging pulmonary and infectious disease research.
| Product Code | H292; H-292; NCI-HUT-292; Hut292; NCIH292 |
| Species | Human |
| Cat.No | ABC-TC488S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
The NCI-H292 cell line offers diverse and valuable applications in biomedical research. Firstly, it can be utilized to evaluate the replication efficiency of certain respiratory viruses within the cell line. Additionally, NCI-H292 cells serve as a substitute cell model for the isolation and propagation of human paramyxoviruses. Moreover, these cells are extensively employed as a model in transfection studies to investigate the role of respiratory viruses and their gene expression in the pathogenesis of respiratory diseases.
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