For research use only
| Cat No. | ABC-TC481S |
| Product Type | Human Leukemia Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pleural Effusion |
| Product Code | PF382 |
PF-382 T-ALL cells, express early and mature T-cell markers, have multiple oncogene mutations, suspension growth, tumorigenicity uncharacterized.
PF-382 is a human T-cell acute lymphoblastic leukemia (T-ALL) cell line established from the pleural effusion of a 6-year-old female patient. The cells display immunosuppressive phenotypic and functional properties. Morphologically, PF-382 cells are single, round to oval shaped, and grow in suspension culture. Cytogenetic analysis reveals a modal chromosome number of 46 with a translocation involving chromosomes X and 15 (t(X;15)(q13;p13)). Immunophenotyping shows expression of early T-cell markers OKT6, Leu-1, Leu-9, and the mature marker OKT8, while lacking CD3 expression and failing to form rosettes with sheep erythrocytes. PF-382 secretes a 47 kDa inhibitory factor that suppresses proliferation of myeloid and erythroid progenitors. Genetic profiling identifies mutations in oncogenes and tumor suppressors including TAL1, CREBBP, HRAS, JAK1, NOTCH1, NRAS, PTEN, and TP53. PF-382 cells exhibit high tumorigenicity in immunodeficient mouse models and demonstrate moderate metastatic potential.
| Product Code | PF382 |
| Species | Human |
| Cat.No | ABC-TC481S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pleural Effusion |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Leukemia Cell Lines |
PF-382 cells uniquely secrete soluble factors that modulate B-cell differentiation, making them a valuable model for studying interactions between T-cell subsets and hematopoietic lineages. This cell line offers significant potential for elucidating regulatory mechanisms governing B-cell development and function, advancing understanding of hematopoiesis.
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