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Primary Cells

Rat Bladder Smooth Muscle Cells

  • For research use only

Cat No.

ABC-TC4082
Product Type

Rat Primary Cells
Cell Type

Smooth Muscle Cell
Species

Rat
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Storage

Liquid Nitrogen

Rat bladder smooth muscle cells, 3-week Wistar rat.

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  • Rat Bladder Smooth Muscle Cells
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Home | Primary Cells | Animal Primary Cells | Rat Primary cells | Rat Bladder Smooth Muscle Cells

Description

Rat Bladder Smooth Muscle Cells (RBSMC) are primary smooth-muscle cells enzymatically isolated from the detrusor muscle layer of pathogen-free adult Sprague-Dawley rats. They are cryopreserved at an early passage during the log-phase to maintain their contractile phenotype. In vitro the cells display elongated, spindle-shaped morphology, align in parallel bundles and generate spontaneous contractile activity, closely mirroring native detrusor behavior. They express α-smooth-muscle actin (α-SMA). Under pathological conditions, such as mechanical over-distention, oxidative stress or hyperglycemia, the cells recapitulate disease-associated changes, including apoptosis, collagen deposition and altered ion-channel expression resembling overactive or under-active bladder phenotypes. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

Rat Bladder Smooth Muscle Cells, Rat Bladder SMCs, Bladder SMCs
Species

Rat
Cat.No

ABC-TC4082
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Smooth Muscle Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Rat Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • RBSMCs provide an adaptable platform for dissecting storage–voiding disorders. Researchers employ them to screen pharmacological agents targeting antimuscarinic, β₃-adrenergic or ion-channel modulators, investigate TRP, BK and KV channel signaling that shapes detrusor excitability, study sex-hormone or metabolic influences on contractility and evaluate anti-fibrotic gene or cell therapies aimed at reversing outlet-obstruction or diabetic cystopathy. Their reliable Ca²⁺-imaging, collagen-gel contraction and traction-force assays accelerate high-content drug discovery while reducing reliance on animal strips. In tissue engineering, RBSMCs are used to seed 3D hydrogels or bladder-on-chip devices, supporting development of functional detrusor patches and integrated urothelial-neuronal co-cultures for mechanistic and translational research.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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