Rat Calvarial Osteoblasts

Description

Rat Calvarial Osteoblasts are primary bone-forming cells isolated from the calvarial bones of neonatal rats. These osteoblasts exhibit a polygonal to spindle-shaped morphology and adhere firmly to culture surfaces. They are cryopreserved at an early passage to retain osteogenic potential and responsiveness. These cells play a critical role in bone matrix synthesis and mineralization by producing type I collagen, osteocalcin, and alkaline phosphatase. Functionally, they contribute to bone remodeling and are highly responsive to hormonal and mechanical stimuli, making them valuable for studying osteoporosis, bone healing, and implant biocompatibility. Rat calvarial osteoblasts typically express alkaline phosphatase (ALP). Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.