Rat Pulmonary Artery Fibroblasts

Description

Rat Pulmonary Artery Fibroblasts (RPAFs) are isolated from the adventitial layer of the pulmonary artery in rats. These cells are a key component of vascular connective tissue and play a crucial role in maintaining vascular structure and function. RPAFs are crucial in synthesizing and remodeling extracellular matrix (ECM) components, including collagen and elastin, thereby contributing to vascular integrity and repair. They also participate in paracrine signaling, releasing cytokines and growth factors that modulate vascular tone and inflammation. These cells highly express Vimentin. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.