Rat Pulmonary Artery Smooth Muscle Cells

Description

Rat Pulmonary Artery Smooth Muscle Cells (RPASMCs) are specialized contractile cells derived from the tunica media of pulmonary arteries. RPASMCs exhibit a spindle-shaped or elongated structure with a central nucleus and abundant actin-myosin filaments, which are essential for their contractile function. RPASMCs regulate vascular resistance through contraction and relaxation, mediated by calcium-dependent signaling pathways. These cells play a critical role in regulating vascular tone and blood pressure in the pulmonary circulation. RPASMCs highly express smooth muscle cell-associated markers including α-SMA, SM-MHC and calponin. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.