For research use only
| Cat No. | ABC-TC0111 |
| Product Type | Human Lung Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Lung Cancer |
| Product Code | CaLu-3; CALU-3; Calu 3; Calu3; CALU3 |
Calu-3, a polarized lung adenocarcinoma line, forms tight junctions, secretes mucins, models drug transport, CFTR function, and airway tumor biology.
Calu-3 cell line, derived from the pleural effusion of a 25-year-old male with lung adenocarcinoma, exhibits adherent, cuboidal-to-polygonal growth as polarized monolayers with tight junctions (ZO-1), microvilli, and E-cadherin expression. Genetically hypotriploid with marker chromosomes, it harbors a homozygous TP53 p. Met237Ile mutation, CDKN2A deletion, ERBB2 amplification, and wild-type KRAS/EGFR. Functionally, it retains CFTR chloride channel activity (akin to bronchial gland cells) and develops high transepithelial resistance, making it ideal for airway physiology, drug transport, and cystic fibrosis studies. Its tumorigenicity in nude mice and metastatic origin support cancer metastasis research, while its permissiveness to SARS-CoV-2 enables respiratory virology and antiviral drug testing. Calu-3’s unique genetic and functional profile solidifies its role in lung cancer, epithelial barrier function, and infectious disease modeling.
| Product Code | CaLu-3; CALU-3; Calu 3; Calu3; CALU3 |
| Species | Human |
| Cat.No | ABC-TC0111 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Lung Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
Calu-3 cells have broad utility in pulmonary studies. They can be used to model the airway epithelial barrier, offering crucial perspectives on respiratory biology. The utilization of this cell line holds value in the in vitro propagation of SARS-CoV-2, serving as an ideal target for gene delivery experiments, and offering significant applications in the realms of cancer and toxicology research. Calu-3 cells also serve as a respiratory model for investigating the effects of gases, duration, physical strain, and biological stimuli on human airway epithelial cells.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
