For research use only
| Cat No. | ABC-TC0133 |
| Product Type | Human Pancreas Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Pancreatic Ductal Adenocarinoma |
| Product Code | CFPac-1; CF PAC-1; CF-PAC1; CF-Pac1; CF Pac1; CFPAC1; CFPac1; CFPAC |
CFPAC-1 cell line is derived from human pancreatic adenocarcinoma and utilized for cystic fibrosis, oncology, and pancreatic cancer therapeutic studies.
CFPAC‑1 is a human pancreatic ductal adenocarcinoma cell line established from a liver metastasis of a 26-year-old Caucasian male with cystic fibrosis. The cells display epithelial morphology, featuring polarization, apical microvilli, tight junctions, and gap junctions, and grow as adherent monolayers. Karyotypically, they are hyperdiploid with multiple translocations, and harbor the ΔF508 CFTR mutation typical of cystic fibrosis. CFPAC‑1 expresses epithelial cytokeratins and oncofetal markers, along with high levels of CA19‑9, CEA, POA, and ACAA. Functional CFTR activity is demonstrated by chloride ion transport responses to Ca²⁺ ionophores. The line is tumorigenic in nude mice and forms tumors efficiently. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.
| Product Code | CFPac-1; CF PAC-1; CF-PAC1; CF-Pac1; CF Pac1; CFPAC1; CFPac1; CFPAC |
| Species | Human |
| Cat.No | ABC-TC0133 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Disease | Pancreatic Ductal Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
CFPAC‑1 serves as a robust model for pancreatic cancer research, especially for exploring cystic fibrosis-related tumorigenesis and CFTR function. It is widely used in preclinical assays for drug response and apoptosis induction — for instance, with agents like cucurmosin targeting PI3K/Akt/mTOR pathways. Its epithelial differentiation and tumorigenic potential enable xenograft studies in nude mice. CFPAC‑1 also features prominently in proteomic analyses to assess gemcitabine sensitivity, particularly regarding apoptotic and DNA repair pathways. With stable expression of CA19‑9, CEA, and keratins, this line is ideal for biomarker validation, chemotherapeutic testing, and functional genomics in pancreatic adenocarcinoma research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
