For research use only
| Cat No. | ABC-TC0156 |
| Product Type | Human Colon Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colon Adenocarinoma |
| Product Code | COLO_320DM; COLO-320-DM; COLO #320DM; COLO320/DM; COLO320-DM; COLO320DM; Colo320DM; COLO320 DM; COLO 320 DM; COLO 320 (DM); Colorado 320 Double Minutes |
COLO-320DM is a human colon adenocarcinoma cell line used in colorectal cancer research, gene amplification studies, and chemotherapy sensitivity assays.
COLO-320 DM cell line was established from ascites fluid of a 55-year-old female with colorectal adenocarcinoma. Morphologically, they grow as floating aggregates with round to polygonal shapes. Gene expression profiling shows MYC amplification, TP53 mutation (R273C), and APC mutation, making them unique for studying APC-independent colorectal carcinogenesis. The cells express both epithelial (CK20) and neuroendocrine markers (chromogranin A). These cells exhibit aggressive tumorigenic properties, including rapid proliferation and neuroendocrine differentiation. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.
| Product Code | COLO_320DM; COLO-320-DM; COLO #320DM; COLO320/DM; COLO320-DM; COLO320DM; Colo320DM; COLO320 DM; COLO 320 DM; COLO 320 (DM); Colorado 320 Double Minutes |
| Species | Human |
| Cat.No | ABC-TC0156 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Growth Mode | Adherent and Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Colon |
| Disease | Colon Adenocarinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Colon Cancer Cell Lines |
COLO-320 DM cells serve as an exceptional model for studying high-grade colorectal adenocarcinoma with neuroendocrine features, particularly for investigating TP53 gain-of-function mutations (R273C) and MYC-driven oncogenesis. Their unique floating aggregate morphology and dual epithelial-neuroendocrine phenotype make them ideal for research on tumor heterogeneity, cancer stem cell properties, and metastatic progression. These cells are widely used in drug resistance studies, xenograft modeling, and screening of targeted therapies against aggressive CRC subtypes, as well as for exploring neuroendocrine transdifferentiation mechanisms in colorectal cancer.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
