For research use only
| Cat No. | ABL-TC0170 |
| Product Type | Human Lung Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Product Code | EBC-1/original; EBC1 |
EBC-1 cells are human lung squamous carcinoma cells with p53 mutation and Met gene amplification,used extensively in invasion, metastasis, and therapeutic.
EBC-1 cell line is a human non-small cell lung carcinoma (NSCLC) cell line derived from the metastatic lymph node of a 70-year-old Japanese male. These cells exhibit classic epithelial morphology and retain key biomarkers of squamous cell carcinoma. EBC-1 cells harbor genetic alterations typical of lung squamous carcinoma, including EGFR amplification and TP53 mutations, making them a robust model for studying tumor progression, drug resistance, and metastasis. They express markers such as cytokeratins and EpCAM, confirming their epithelial origin. A defining feature of the EBC-1 cell line is its MET exon 14 skipping mutation, leading to constitutive MET receptor tyrosine kinase activation, which drives oncogenic signaling and makes this cell line highly sensitive to MET inhibitors.
| Product Code | EBC-1/original; EBC1 |
| Species | Human |
| Cat.No | ABL-TC0170 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Lung Cancer Cell Lines |
EBC-1 cells are widely used in cancer research, particularly for studying lung squamous cell carcinoma pathogenesis, drug screening, and molecular mechanisms of MET signaling. Their MET amplification makes them ideal for evaluating MET-targeted therapies (e.g., crizotinib). Additionally, they serve as a model for invasion assays, xenograft studies, and biomarker discovery in NSCLC. Their genetic stability and well-characterized mutations support translational research in precision oncology.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
These cells are derived from a Japanese male with non-small cell lung carcinoma.
The medium should be changed every 2-3 days.
Approximately 1-2×10^4 cells/cm².
Surface Quality: Ensure the culture vessels are tissue culture-treated.
Coating: Use extracellular matrix proteins like collagen or fibronectin to enhance adhesion.
Passage Number: Use cells with a lower passage number to avoid adhesion issues due to cellular senescence.
EBC-1 is a human lung cancer cell line derived from squamous cell carcinoma. It is commonly used in cancer research, particularly for studying MET gene amplification, tumor signaling pathways, and anticancer drug response
